Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ACTG320_2650 | 2650 | U.S. | 1996 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 167 |
| 2 | AZT+ DDC | 52 |
| 3 | AZT+ D4T | 13 |
| 4 | AZT | 16 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, D67DN, K70R | K219KQ | R83K, D123E, S162A, I178L, V179I, G196E, T200A, I202V, R211RK, T215X, V245E, A360AV, V365I, A371AT, A376S, T377R, T386TI, E432ED, V435VI, K451R, D460N |
| >2650| codons 1-491 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDLII YQYMDDLYVGSDLEIEQHRAKVEELRQHLLKWGFXTPDQKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGV HTNDIKQLTETVQKISRESIVIWGKIPKFKLPIQKETWEAWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKDPIIGAETFYVDGAANRETRLGKAGYVTNRGRQKVVSLTDTTNQKTELQ AIHLALQDSGL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| R41K |
| >2650| codons 7-99 QRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYDQILIEI CGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Hammer, SM | A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. | N Engl J Med, 1997 |