<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
ACTG320_2650 2650 U.S. 1996 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 167
2 AZT+ DDC 52
3 AZT+ D4T 13
4 AZT 16

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41ML, D67DN, K70R K219KQ     R83K, D123E, S162A, I178L, V179I, G196E, T200A, I202V, R211RK, T215X, V245E, A360AV, V365I, A371AT, A376S, T377R, T386TI, E432ED, V435VI, K451R, D460N  
>2650| codons 1-491
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV
FAIKKKNSTRWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDLII
YQYMDDLYVGSDLEIEQHRAKVEELRQHLLKWGFXTPDQKHQKEPPFLWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGV
HTNDIKQLTETVQKISRESIVIWGKIPKFKLPIQKETWEAWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKDPIIGAETFYVDGAANRETRLGKAGYVTNRGRQKVVSLTDTTNQKTELQ
AIHLALQDSGL

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    R41K  
>2650| codons 7-99
QRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYDQILIEI
CGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF

References
Author Title Citation
Hammer, SM A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. N Engl J Med, 1997