<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
ACTG320_2574 2574 U.S. 1996 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 121
2 AZT+ DDI 93
3 AZT+ DDI+ DDC+ NVP 104

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L210W, T215Y K219N K101E, Y181C, G190A   V35VIM, T39TA, K43N, E44D, V118I, K122E, D123E, I135T, S162C, D177E, I178M, G196E, T200I, L228LH, A272P, R284K, A288S, I293V, D324E, I326L, R358K, G359S, T386V, A400T, T403M, V435I, V466A, L469LI  
>2574| codons 1-481
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAELENDGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSIPL
DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPEMVI
CQYMDDLYVASDLEIEQHRIKIEELRQHLWRWGFYTPDNKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLKGTKSLTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKELLAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMKSA
HTNDVKQLTEAVQKIATESIVIWGKVPKFKLPIQKETWETWWMEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIIGAETFYVDGAANRETKLGKAGYVTDRGRQKAVSITDTTNQKTELQ
A

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I15V, Q18L, L19I, L63P, I72E, V77I  
>2574| codons 1-99
PQITLWQRPLVTIKVGGLIKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD
QIPIEICGHKAEGTVLIGPTPVNIIGRNLLTQIGCTLNF

References
Author Title Citation
Hammer, SM A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. N Engl J Med, 1997