Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ACTG320_2571 | 2571 | U.S. | 1996 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 156 |
| 2 | D4T | 52 |
| 3 | None | 17 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R | K219Q | T39TA, V60I, T69N, K82KR, K103R, I135AT, G196E, F214L, K277R, V317A, G335S, G359S, I375V, A376S, S379C, K390R, V435A, G436E |
| >2571| codons 1-492 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAEMEKEGKISKIGPENPYNTPI FAIKKKNSNRWRKLVDFRELNRRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRTKIEELRQHLLRWGLTTPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTEVIPLTEEAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQGQSQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEAVQKVSTECIVIWGKTPKFRLPIQKETWEAWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIAEAETFYVDGAANRETKLGKAGYVTDRGRQKVVSLTDTTNQKTELQ AIHLALQDSGLE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12A, K14KR, N37ND, R41K, I64V |
| >2571| codons 1-99 PQITLWQRPLVAIRIGGQLKEALLDTGADDTVLEEMDLPGKWKPKMIGGIGGFIKVRQYD QILVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Hammer, SM | A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. | N Engl J Med, 1997 |