Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ACTG320_2523 | 2523 | U.S. | 1996 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 208 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, T215F | K219Q | K20R, E138A, K166KR, G196GE, I202V, R211K, P243Q, V245VEKM, A272P, K277R, T286A, D324DE, M357T, A371V, A376T, K390R, A400T, T403L, A446S, K454KR, H483Y |
| >2523| codons 1-493 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRTKVEELRQHLLKWGFFTPDQKHQKEPPFLWMGYELHPDKWT VQQIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLTEVVQKITTESIVIWGKTPKFRLPIQKETWETWWLEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIVGAETFYVDGASNRETKLGRAGYVTDRGRQKVVSLTDTTNQKTELQ AIYLALQDSGLEV |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| K14KR, Q18QH, L19LIM, N37H, R57K, L63P, H69HR, K70E, V77I |
| >2523| codons 7-99 QRPLVTIRIGGHMKEALLDTGADDTVLEEMHLPGRWKPKMIGGIGGFIKVKQYDQIPIEI CGREAIGTVLIGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Hammer, SM | A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. | N Engl J Med, 1997 |