<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
ACTG320_2516 2516 U.S. 1996 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 44
2 AZT+ DDI 64
3 AZT 94
4 AZT+ D4T 30

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
K70R D67G, K219Q     V35M, S68G, D177DE, I178M, G196GE, I202IV, Q207H, R211K, A272P, K277R, T286TA, E297K, E312EA, V317A, D324P, I329V, G333E, G335S, V365I, A376S, T386I, D460N, L469F  
>2516| codons 1-479
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTEMEKEGKISKIGPENPYNTPV
FAIKKKGGTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI
YQYMDDLYVGSDLEIEQHRTKVEELRHHLLKWGFTTPDQKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTKEAE
LELAENREILKAPVHGAYYDPSKPLIAEVQKQEQSQWTYQIYQEPFKNLKTGKYARMRGA
HTNDIKQLTEAVQKISTESIVIWGKIPKFKLPIQKETWEAWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVSFTDTTNQKTEL

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    N37D, K45KR, D60E, I62V, L63P, V77I, I93L  
>2516| codons 1-99
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPRMIGGIGGFIKVRQYE
QVPIEICGHKAIGTVLIGPTPVNIIGRNLLTQLGCTLNF

References
Author Title Citation
Hammer, SM A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. N Engl J Med, 1997