<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
ACTG320_2339 2339 U.S. 1996 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 DDI+ AZT 87

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, K70R, T215F K219Q     K64KN, D121DN, E203ED, R211K, D218DE, A272P, T286A, A288AG, I293IV, E297K, K311R, I326V, G333E, Q334I, M357MT, K366KR, T369AV, A371V, I375V, A376T, T377TIM, K390R, A400T, T419TI, V435VAIT, D460N, R461K, S468T, H483Y  
>2339| codons 1-483
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAINKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
NKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIDELRQHLLKWGFFTPEQKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKGLTEVVPLTKEAE
LELAENREILREPVHGVYYDPSKDLVAEIQKQEIGQWTYQIYQEPFKNLKTGKYARTRGA
HTNDVRQLVEVVQKVTMESIVIWGKTPKFRLPIQKETWETWWTEYWQATWIPEWEFVNIP
PLVKLWYQLEKEPITGAETFYVDGAANRETKLGKAGYVTNKGRQKVVTLTDTTNQKTELQ
AIY

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12Q, K14E, I15V, K20R, E35D, M36I, I62V, L63S, E65K  
>2339| codons 1-99
PQITLWQRPLVQIEVGGQLREALLDTGADDTVLEDINLPGRWKPKMIGGIGGFIKVRQYD
QVSIKICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF

References
Author Title Citation
Hammer, SM A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. N Engl J Med, 1997