Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ACTG320_2339 | 2339 | U.S. | 1996 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI+ AZT | 87 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, T215F | K219Q | K64KN, D121DN, E203ED, R211K, D218DE, A272P, T286A, A288AG, I293IV, E297K, K311R, I326V, G333E, Q334I, M357MT, K366KR, T369AV, A371V, I375V, A376T, T377TIM, K390R, A400T, T419TI, V435VAIT, D460N, R461K, S468T, H483Y |
| >2339| codons 1-483 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAINKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL NKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIDELRQHLLKWGFFTPEQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKGLTEVVPLTKEAE LELAENREILREPVHGVYYDPSKDLVAEIQKQEIGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVRQLVEVVQKVTMESIVIWGKTPKFRLPIQKETWETWWTEYWQATWIPEWEFVNIP PLVKLWYQLEKEPITGAETFYVDGAANRETKLGKAGYVTNKGRQKVVTLTDTTNQKTELQ AIY |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12Q, K14E, I15V, K20R, E35D, M36I, I62V, L63S, E65K |
| >2339| codons 1-99 PQITLWQRPLVQIEVGGQLREALLDTGADDTVLEDINLPGRWKPKMIGGIGGFIKVRQYD QVSIKICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Hammer, SM | A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. | N Engl J Med, 1997 |