Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ACTG320_2337 | 2337 | U.S. | 1996 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 98 |
| 2 | DDI | 35 |
| 3 | AZT | 32 |
| 4 | AZT+ DDI | 71 |
| 5 | DDI | 79 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L210W, T215Y | K219N | K20R, V35E, T39A, E40F, K43E, V118I, K122KE, E138G, I142T, S162C, G196E, Q207E, R211K, V245VE, A272P, K277R, I293V, E297A, G333E |
| >2337| codons 1-334 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALEEICAFLEEEGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNGTPGTRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRTKIEELREHLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQEQ |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| K14KR, R41K, L63A, V82I |
| >2337| codons 1-99 PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QIAIEICGHKAIGTVLVGPTPINIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Hammer, SM | A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. | N Engl J Med, 1997 |