<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
ACTG320_1853 1853 U.S. 1996 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 217
2 None 31
3 D4T 4
4 None 27

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        I142V, T200I, R211K, V245VE, E248ED, K249Q, A272S, T286A, K311R, S322A, G333E, R356K, A360AT, A376V, K385R, K390R, A400T, V435E, A437V, V458I  
>1853| codons 1-482
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRIKIEELRQHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIELPDQDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGAKALTEVIPLTEEAE
LELAENREILREPVHGVYYDPAKDLIAEIQKQEQGQWTYQIYQEPFKNLKTGKYAKMRGT
HTNDVKQLTEAVQKIVTESIVIWGRTPKFRLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIEGVETFYVDGAANRETKLGKAGYITDRGRQKVVSLTDTTNQKTELQ
AI

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I15IV, Q61QE, L63P, V77VI, I93L  
>1853| codons 9-99
PLVTIKVGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYDEIPIEICG
HKAIGTVLIGPTPVNIIGRNLLTQLGCTLNF

References
Author Title Citation
Hammer, SM A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. N Engl J Med, 1997