Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ACTG320_1824 | 1824 | U.S. | 1996 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 181 |
| 2 | AZT+ DDI+ NVP | 134 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, T215F | K219Q | K101E, Y181C, G190A | V35L, L109LIM, D123E, I135T, T139M, S162Y, D177E, I202V, L228H, E248D, D250E, A272P, T286A, K390R, K395R, E399D, A400S, E404D, V435M, K454R, K465R, A481S |
| >1824| codons 1-488 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVMDVGDAYFSVPL DKEFRKYTAFTIPSTNNEMPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPEIVI CQYMDDLYVASDLEIGQHRTKVEELRQHLLRWGFFTPDQKHQKEPPFHWMGYELHPDKWT VQPIVLPDKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQRETWDSWWTDYWQATWIPEWEFVNTP PLVKLWYQLEKEPIMGAETFYVDGAANRETKLGRAGYVTDRGRQRVVSLTDTTNQKTELQ SIHLALQD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10I, K14KR, L19I, L63P, H69Q |
| >1824| codons 9-99 PIVTIRIGGQIKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYDQIPIEICG QKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Hammer, SM | A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. | N Engl J Med, 1997 |