Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ACTG320_1817 | 1817 | U.S. | 1996 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DLV+ AZT | 48 |
| 2 | AZT+ DLV+ DDC | 19 |
| 3 | AZT+ DDC | 4 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K219N | K103N, M230L | K22R, V35VL, K43KN, E44D, W88C, V90VI, V118VI, I178L, T200A, E203ED, H208Y, R211K, H221HY, K277R, T286A, E297A, S322T, D324E, A376T, T386I, Q394L, D460N, R461K, L469I, H483L | K64KHNQ |
| >1817| codons 1-494 PISPIETVPVKLKPGMDGPKVRQWPLTEEKIKALLEICTELENDGKISKIGPENPYNTPV FAIQKKNSTKWRKLVDFRELNKRTQDFCEIQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVI YQYMDDLYVGSDLEIGQHRAKIDELRQYLWKWGFYTPDNKYQKEPPFLWLGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTEVIPLTAEAE LELAENREILKEPVHGVYYDPTKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEAVQKITTESIVIWGKIPKFKLPILKETWEAWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNKGRQKVVSITDTTNQKTELQ AILLALQDSGLEVN |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| E35ED, N37AT, L63P, V77I |
| >1817| codons 11-99 VTIKIGGQLKEALLDTGADDTVLEDMTLPGRWKPKMIGGIGGFIKVRQYDQIPIEICGHK AIGTVLIGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Hammer, SM | A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. | N Engl J Med, 1997 |