<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
ACTG320_1736 1736 U.S. 1996 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 477

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        K122KE, S162A, V245X, E248ED, D250DE, S251SN, A272P, I293V, G333E, Q334H, G359S, I375V, A376S, T377M, T386TI, T403M, E432D, V435VI, A446S  
>1736| codons 1-492
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIXLPDKENWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQEHGQWTYQIYQEPFKNLKTGKYARMRSA
HTNDVKQLTEAVQKVSMESIVIWGKIPKFKLPIQKETWEAWWMEYWQATWIPEWEFVNTP
PLVKLWYQLEKDPIIGAETFYVDGASNRETKLGKAGYVTDRGRQKVVSLTDTTNQKTELQ
AIHLALQDSGLE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    L63LP  
>1736| codons 20-99
KEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYDQIPIEICGHKAIGTVLVGP
TPVNIIGRNLLTQIGCTLNF

References
Author Title Citation
Hammer, SM A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. N Engl J Med, 1997