<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
ACTG320_1410 1410 U.S. 1996 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 220

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, T69D, K70R, T215FI K219Q     K103KR, K104KN, K122E, D123N, I135T, R211T, F214L, I244V, V245MT, A272P, Q278QH, I293V, M357T, E370ED, A376T, K390KR, A400T, A437AV, A446AS, N447NS, K451KR, H483Y  
>1410| codons 1-487
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRNSVTVLDVGDAYFSVPL
DENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLTWGLITPDQKHQKEPPFLWMGYELHPDKWT
VQPVTLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKHLCKLLRGTKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA
HTNDVKQLTDAVQKITTESIVIWGKTPKFRLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGVETFYVDGASSRETRLGKAGYVTDRGRQKVVSLTDTTNQKTELQ
AIYLALQ

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12E, M36I, R41K, L63P, I64IV, K70KR, I72IV  
>1410| codons 1-99
PQITLWQRPLVEIKIGGQLKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD
QIPVEICGHRAVGTVLVGPTPVNIIGRNLLTQIGCTLNF

References
Author Title Citation
Hammer, SM A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. N Engl J Med, 1997