Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ACTG320_1373 | 1373 | U.S. | 1996 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 8 |
| 2 | AZT+ DDC | 60 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67DN, L210W, T215Y | V35VI, E44ED, K122P, A158AS, P176PS, D177DE, I178L, V179I, G196E, A272P, K275R, K277Q, T286TA, E291D, V292I, I293IV, E297R, K311KR, S322A, R358RK, K366R, T369TP, A376T, V381I, E399D, A400T, T403S, V435M, L452M, D460N, Q475X |
| >1373| codons 1-475 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DPDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPSIFQSSMTKILEPFRKQNSELII YQYMDDLYVGSDLEIEQHRTKIEELRQHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVQQLCKLLRGAKALTDIVPLTREAE LELAENREILREPVHGVYYDPAKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMKGA HTNDVRQLPEAVQKITTESIIIWGKTPKFKLPIQKETWDTWWSEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIMGAETFYVDGAANRETKMGKAGYVTNRGRQKVVSLTDTTNH |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I13V, L63AP, V77I |
| >1373| codons 1-99 PQITLWQRPLVTVKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLIGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Hammer, SM | A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. | N Engl J Med, 1997 |