Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ACTG320_1321 | 1321 | U.S. | 1996 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | NVP | NA |
| 2 | AZT | 79 |
| 3 | None | 12 |
| 4 | DDI | 85 |
| 5 | None | 121 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V | T215C | Y181C | A98G | V35VE, T39A, K49R, I50V, R83K, K122E, A272AP, I293V, T296S, E297A, L301M, M357V, S379G, V381I, K385R, K390R, A400T, E404D, K451KR, D460N, H483HY |
| >1321| codons 1-484 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALEEICAELEKEGKISRVGPENPYNTPV FAIKKKDSTKWRKVVDFRELNKKTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFCTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLSAEAE MELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARVRGA HTNDVKQLTEAVQKIATEGIIIWGRTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP PLVKLWYQLEKEPIVGAETFYVDGAANRETRLGKAGYVTNRGRQKVVSLTDTTNQKTELQ AIYL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L63AT, I72T, V77I, L89M |
| >1321| codons 13-99 IKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYDQITIEICGHKAT GTVLIGPTPVNIIGRNMLTQIGCTLNF |
References
| Author | Title | Citation |
| Hammer, SM | A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. | N Engl J Med, 1997 |