Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ACTG320_13 | 13 | U.S. | 1996 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 77 |
| 2 | None | 3 |
| 3 | DLV+ DDI | 67 |
| 4 | DDI | 4 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, L74V, T215Y | Y181C | V108VI | K20KR, A98S, K122P, K166R, D177E, T200A, Q207E, H221HY, P243S, E248ED, K277R, L283I, I293V, E297R, R356K, R358RK, A360AT, I375V, T377A, K390R, E399D, T403M, V435A, A446S, Q480H |
| >13| codons 1-484 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTILDVGDAYFSVPL DPDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPEIVI CQYMDDLYVGSDLEIGQHRAKIEELREHLLRWGFYTPDKKYQKEPPFLWMGYELHPDKWT VQSIVLPDKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLIRGTKALTEVVPLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMKGT HTNDVKQLTEAVQKVAAESIVIWGKTPKFRLPIQKETWDAWWMEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIAGAETFYVDGASNRETKLGKAGYVTDRGRQKVVSLTDTTNQKTELH AIHL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L33LV, R41K, R57K, D60E, I64V |
| >13| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVVEEMNLPGKWKPKMIGGIGGFIKVKQYE QILVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Hammer, SM | A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. | N Engl J Med, 1997 |