<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
ACTG320_1213 1213 U.S. 1996 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 33
2 AZT+ DDI+ NVP 140

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74V, L210W, T215Y   Y181V A98G V35M, T39A, K43E, E44A, R83K, K102Q, V118I, D123E, I195L, G196GE, E203K, H208HY, R211K, K223E, L228H, A272P, T286A, E297K, D324E, Q334L, G335S, R356RK, G359S, K366R, A371V, A376T, K390R, A400T, V435I, K451R, V458I, R461RK  
>1213| codons 1-483
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAELEEAGKISKIGPENPYNTPV
FAIKKKDSTKWRKVVDFRELNKKTQDFWEVQLGIPHPGGLKQKKSVTVLDVGDAYFSIPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
VQYMDDLYVGSDLELEQHRTKIKELRQYLWKWGFYTPDKKHQEEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTKEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQGLSQWTYQIYQEPFKNLKTGKYAKMRSA
HTNDVRQLTEVVQKITTESIVIWGKTPKFRLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIIGAETFYVDGAANRETRLGKAGYITDKGRQKVVSLTDTTNQKTELQ
AIH

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I13V, E35D, N37S, I62IV, L63HP, I64V, V77VI  
>1213| codons 11-99
VTVKIGGQLKEALLDTGADDTVLEDMSLPGRWKPKMIGGIGGFIKVRQYDQVPVEICGHK
AIGTVLIGPTPVNIIGRNLLTQIGCTLNF

References
Author Title Citation
Hammer, SM A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. N Engl J Med, 1997