<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
ACTG320_1191 1191 U.S. 1996 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 DDC+ AZT 77

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L210W, T215Y       K20R, V35I, T39TA, E44D, R83RK, K104KR, V118VI, K122KE, T200TA, H208HY, R211K, L228LR, A272AS, R284K, I293V, S322AE, D324DE, Q334L, M357T, A371V, I375IV, A376T, T377L, T386I, A400T, V435VA, D460N, H483Q  
>1191| codons 1-484
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICAELEKDGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKRSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRAKIEELRQYLWKWGFYTPDKKHQKEPPFRWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLKGTKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPEKELIAEIQKQGLGQWTYQIYQEPFKNLKTGKYARTRGA
HTNDVKQLTEVVQKVTLESIVIWGKIPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIAGAETFYVDGAANRETKLGKAGYVTNRGRQKVVSLTDTTNQKTELQ
AIQL

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    L19Q, R41K, L63AITV  
>1191| codons 12-99
TIKIGGQQKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYDQIVIEICGHKA
IGTVLVGPTPVNIIGRNLLTQIGCTLNF

References
Author Title Citation
Hammer, SM A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. N Engl J Med, 1997