<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
ACTG320_1166 1166 U.S. 1996 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 57

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        K20R, R211RK, K277R, I293IV, K311KR, P313T, Y319F, G333E, Q334H, T386I, A400T, Y405H, V435A, L452LI  
>1166| codons 1-490
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTEVVPLTEEAE
LELAENREILRETVHGVYFDPSKDLIAEIQKQEHGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKIATESIVIWGKIPKFKLPIQKETWETWWTEHWQATWIPEWEFVNTP
PLVKLWYQLEKEPIAGAETFYVDGAANRETKIGKAGYVTDRGRQKVVSLTDTTNQKTELQ
AIHLALQDSG

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12N, L19I, E35D, N37NY, R41K, L63T, V77VI, T91V, I93L M36MR
>1166| codons 1-99
PQITLWQRPLVNIKIGGQIKEALLDTGADDTVLEDRYLPGKWKPKMIGGIGGFIKVRQYD
QITIEICGHKAIGTVLIGPTPVNIIGRNLLVQLGCTLNF

References
Author Title Citation
Hammer, SM A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. N Engl J Med, 1997