Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ACTG320_1131 | 1131 | U.S. | 1996 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 134 |
| 2 | AZT+ DDC | 104 |
| 3 | AZT | 95 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T215CY | K20KR, D123E, I142V, S162C, Q197E, R211K, K277R, I293V, G333E, P345Q, G359GS, A371AV, T386I, K390R, E396D, A400T, D460N, R461K, S468T, Q487X |
| >1131| codons 1-487 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGEHRTKIEELRQHLLKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQEQGQWTYQIYQEQFKNLKTGKYARMRSA HTNDVKQLTEVVQKIATESIVIWGKIPKFRLPIQKDTWETWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNKGRQKVVTLTDTTNQKTELQ AIHLALH |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L33LV, N37AGST, I62IV, L63LP, I64V |
| >1131| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVVEEMTLPGRWKPKMIGGIGGFIKVRQYD QVPVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Hammer, SM | A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. | N Engl J Med, 1997 |