Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ACTG320_1057 | 1057 | U.S. | 1996 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 119 |
| 2 | AZT+ DDI | 29 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69TADN, K70R, T215TFIS | K219Q | V35R, T39A, K103R, R211RK, F214L, K277R, T286TA, I293V, E297K, S322T, Y342F, R356RK, A360T, A376T, K390R, A400T, D460N, R461K, L469I |
| >1057| codons 1-482 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALREICAEMEKEGKISKIGPENPYNTPV FAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGLSTPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPTKDLIAEIQKQGQGQWTYQIFQEPFKNLKTGKYAKMRGT HTNDVKQLTEAVQKITTESIVIWGKTPKFRLPIQKETWETWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNKGRQKVVSITDTTNQKTELQ AI |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| K14R, E35D, N37E, K55KR, L63P, A71T, V77I |
| >1057| codons 9-99 PLVTIRIGGQLKEALLDTGADDTVLEDMELPGRWKPKMIGGIGGFIRVRQYDQIPIEICG HKTIGTVLIGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Hammer, SM | A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. | N Engl J Med, 1997 |