Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ACTG320_1031 | 1031 | U.S. | 1996 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 283 |
| 2 | None | 4 |
| 3 | DDI | 29 |
| 4 | AZT | 6 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, T215F | K219Q | K20KR, D123E, I135T, G196E, Q207E, R211K, V245K, T286A, I293V, D324E, G333E, R358RK, D364E, T377R, T403V, E404D, Y405H, N418S, V435I, R461K, L469I, T470P |
| >1031| codons 1-487 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRTKIEELREHLLKWGFFTPDQKHQKEPPFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQEQGQWTYQIYQEPFKNLKTGKYARMKGA HTNEVKQLTEAVQKIARESIVIWGKTPKFKLPIQKETWEAWWVDHWQATWIPEWEFVSTP PLVKLWYQLEKEPIIGAETFYVDGAANRETKLGKAGYVTDKGRQKVVSIPDTTNQKTELQ AIHLALQ |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12E, L19I, R41K, D60E, I62IV, I64V |
| >1031| codons 1-99 PQITLWQRPLVEIKIGGQIKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYE QVLVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Hammer, SM | A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. | N Engl J Med, 1997 |