Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ACTG320_1000 | 1000 | U.S. | 1996 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI+ AZT | 140 |
| 2 | D4T | 3 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, T215FY | K219Q | V35I, E44ED, I50V, D123E, D177E, I178IM, E203D, V245T, A272P, K277R, P294T, E297R, G333E, Q334HY, R356K, G359GS, V365VI, T377S, K390R, T403AV, K431T, L452M, T470S, L486X |
| >1000| codons 1-486 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKDGKISKVGPENPYNTPV FAIKKKNSTRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI YQYMDDLYVGSDLEIGQHRTKIDELRQHLLRWGFYTPDQKHQKEPPFLWMGYELHPDKWT VQPITLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVITLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQEYGQWTYQIYQEPFKNLKTGKYAKMRSA HTNDIKQLTEAVQKIASESIVIWGKTPKFRLPIQKETWEAWWVEYWQATWIPEWEFVNTP PLVKLWYQLETEPIVGAETFYVDGAANRETKMGKAGYVTDRGRQKVVSLSDTTNQKTELQ AIHLAF |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L33I | E35D, N37S, L63P, V77I |
| >1000| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVIEDMSLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLIGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Hammer, SM | A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. | N Engl J Med, 1997 |