<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
ACTG320_1000 1000 U.S. 1996 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 DDI+ AZT 140
2 D4T 3

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L74I, T215FY K219Q     V35I, E44ED, I50V, D123E, D177E, I178IM, E203D, V245T, A272P, K277R, P294T, E297R, G333E, Q334HY, R356K, G359GS, V365VI, T377S, K390R, T403AV, K431T, L452M, T470S, L486X  
>1000| codons 1-486
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKDGKISKVGPENPYNTPV
FAIKKKNSTRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI
YQYMDDLYVGSDLEIGQHRTKIDELRQHLLRWGFYTPDQKHQKEPPFLWMGYELHPDKWT
VQPITLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVITLTREAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQEYGQWTYQIYQEPFKNLKTGKYAKMRSA
HTNDIKQLTEAVQKIASESIVIWGKTPKFRLPIQKETWEAWWVEYWQATWIPEWEFVNTP
PLVKLWYQLETEPIVGAETFYVDGAANRETKMGKAGYVTDRGRQKVVSLSDTTNQKTELQ
AIHLAF

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
  L33I E35D, N37S, L63P, V77I  
>1000| codons 1-99
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVIEDMSLPGRWKPKMIGGIGGFIKVRQYD
QIPIEICGHKAIGTVLIGPTPVNIIGRNLLTQIGCTLNF

References
Author Title Citation
Hammer, SM A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. N Engl J Med, 1997