Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| RES075 | RES075 | Brazil | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+IDV | 52 |
| 2 | 3TC+D4T+SQV | 143 |
| 3 | 3TC+D4T+NFV | 9 |
| 4 | 3TC+AZT+EFV+NFV | 65 |
| 5 | APV+D4T+DDI+RTV | 48 |
| 6 | Unknown | 4 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54IV | L10V, I13V, I15V, K20T, E35D, M36I, R41K, R57K, D60E, Q61D, I62V, L63LP, T74TA, V82I, I85V, L89M, I93IL |
| >RES075| codons 1-99 PQITLWQRPVVTVKVGGQLTEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFVKVKQYE DVPIEICGHKAIGAVLVGPTPINIVGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K103KN | P225PH | K20R, V35I, E53ED, D123E, I135T, S162F, D177E, F214FL, A272P, V292I, E297K, Q334L |
| >RES075| codons 1-335 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTEMEKEGKISKIGPDNPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQFSMTKILEPFRKQNPEIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEHPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEIIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLG |
References
| Author | Title | Citation |
| Dumans, AT | Synonymous genetic polymorphisms within Brazilian human immunodeficiency virus Type 1 subtypes may influence mutational routes to drug resistance. | J Infect Dis, 2004 |