Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 273 | 273 | Brazil | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDI | 54 |
| 2 | 3TC+ AZT | 8 |
| 3 | 3TC+ AZT+ RTV | 4 |
| 4 | 3TC+ D4T+ RTV | 173 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74I, M184V, L210W, T215Y | V75A | E44D, V118I, K122E, R211A, K223Q |
| >273| codons 36-225 EICTELEKDGKISKIGPENPYNTPVFAIKKKDSTKWRKIADFRELNKRTQDFWEVQLGIP HPAGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKG SPAIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRTKIEELRQHLWAWGFY TPDKKHQQEP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, V82A, I84V | L24I, L33F | L10I, I13V, E34Q, I62V, L63A, V77I |
| >273| codons 1-99 PQITLWQRPIVTVKIGGQLKEALIDTGADDTVFQEMNLPGRWKPKLIGGIGGFIKVRQYD QVAIEICGHKAIGTVLIGPTPANVIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Dumans, AT | Synonymous genetic polymorphisms within Brazilian human immunodeficiency virus Type 1 subtypes may influence mutational routes to drug resistance. | J Infect Dis, 2004 |