Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| RG018 | RG018 | Brazil | 2002 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI+RTV | 4 |
| 2 | 3TC+AZT+RTV | 4 |
| 3 | 3TC+AZT+SQV | 39 |
| 4 | 3TC+D4T+IDV | 48 |
| 5 | 3TC+D4T+NFV+NVP | 31 |
| 6 | 3TC+D4T+IDV+NVP+RTV | 44 |
| 7 | 3TC+AZT+IDV+RTV | 82 |
| 8 | Unknown | 2 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V82VA | L10I, T12N, I15V, K20R, E35D, M36I, N37T, R41K, K45R, I54X, R57K, Q61N, I62V, L63C, A71AV, T74S, L89IM, I93L |
| >RG018| codons 1-99 PQITLWQRPIVNIKVGGQLREALLDTGADDTVLEDITLPGKWKPRMIGGIGGFXKVKQYD NVCIEICGHKVIGSVLVGPTPANIIGRNILTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70KR, L74LI, M184MV | K219Q | E6D, K20R, A33AG, V35I, V106VI, K122E, I135T, I142M, S162Y, K173T, Q174K, N175NY, T200A, I202IV, E203K, Q207E, R211A, F214L, D218DE, V245Q, E248D, A272P, T286A, E291ED, I293V, P294S, E297T, L325F, G333R, Q334H |
| >RG018| codons 1-335 PISPIDTVPVKLKPGMDGPRVKQWPLTEEKIKGLIEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGMRYQYNVLPQGWKGSPAIFQYSMTKILEPFRTKYPDIVI YQYVDDLYVGSDLEIGQHRAKVKELREHLLAWGLTTPEQKHQKEPPFLWMGYELHPDKWT VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDVVSLTTEAE LELAENREILKEPVHGVYYDPSKDFIAEIQKQRHG |
References
| Author | Title | Citation |
| Dumans, AT | Synonymous genetic polymorphisms within Brazilian human immunodeficiency virus Type 1 subtypes may influence mutational routes to drug resistance. | J Infect Dis, 2004 |