Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| RG008 | RG008 | Brazil | 2002 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+IDV | 83 |
| 2 | D4T+DDI+EFV | 18 |
| 3 | 3TC+AZT+IDV+RTV | 52 |
| 4 | Unknown | 3 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I15V, L19I, K20R, E35D, M36I, N37D, R41K, H69Q, L89M, I93L |
| >RG008| codons 1-99 PQITLWQRPLVTIKVGGQIREALLDTGADDTVLEDIDLPGKWKPKMIGGIGGFIKVRQYD QILIEICGQKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V, T215F | K219E | Y181C | A98G | V35T, T39G, K49R, I135V, S162C, E169D, K173A, Q174K, D177E, G196E, T200A, Q207E, R211K, V245Q, P247A, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, E297A, S322T, I329L |
| >RG008| codons 1-335 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICGEMEKEGKISRIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILDPFRAKNPEIVI CQYVDDLYVGSDLEIEQHRAKIEELREHLLKWGFFTPDEKHQKEPPFLWMGYELHPDKWT VQPIQLADKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVTLTAEAE LELAENREILKEPVHGVYYDPTKDLIAELQKQGQG |
References
| Author | Title | Citation |
| Dumans, AT | Synonymous genetic polymorphisms within Brazilian human immunodeficiency virus Type 1 subtypes may influence mutational routes to drug resistance. | J Infect Dis, 2004 |