Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 252 | 252 | Brazil | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDI | 23 |
| 2 | 3TC+ AZT+ RTV | 12 |
| 3 | 3TC+ D4T+ RTV | 21 |
| 4 | 3TC+ D4T+ NFV | 14 |
| 5 | 3TC+ D4T+ NFV+ NVP | 174 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| N88S, L90M | L10I, L19I, N37S, K45R, L63P, A71T, V77I, I93L |
| >252| codons 1-99 PQITLWQRPIVTIKIGGQIKEALLDTGADDTVLEEMSLPGRWKPRMIGGIGGFIKVRQYD QIPIEICGHKTIGTVLIGPTPVNIIGRSLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V | T215I, K219E | K101E, Y181C, G190A | E44D, V118I, K122E, I135T, T200I, F214L |
| >252| codons 36-225 EICTEMEKDGKISKIGPENPYNTPVFAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIP HPAGLEKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKG SPAIFQSSMTKILEPFRKQNPDIVICQYVDDLYVASDLEIGQHRIKIEELRQHLLRWGLI TPDEKHQKEP |
References
| Author | Title | Citation |
| Dumans, AT | Synonymous genetic polymorphisms within Brazilian human immunodeficiency virus Type 1 subtypes may influence mutational routes to drug resistance. | J Infect Dis, 2004 |