Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| RG070 | RG070 | Brazil | 2002 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 100 |
| 2 | AZT+DDI | 22 |
| 3 | 3TC+AZT | 35 |
| 4 | 3TC+AZT+IDV | 126 |
| 5 | 3TC+AZT+IDV+RTV | 52 |
| 6 | Unknown | 76 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82S | L24I, F53FL, Q58E | L10I, K20R, E35D, M36I, R41K, K55R, R57K, Q61N, I62IV, L63P, A71V, L89M, I93L |
| >RG070| codons 1-99 PQITLWQRPIVTIKIGGQLREALIDTGADDTVLEDINLPGKWKPKIIGGIGGLVRVKEYD NVPIEICGHKVIGTVLVGPTPSNIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, V75M, M184V, L210W, T215Y | K219Q | P4S, K20KR, V35VI, T39A, K43KN, E44D, D123E, S162Y, K173T, Q174K, T200A, Q207A, H208Y, R211K, W212C, D218E, L228H, V245Q, E248D, A272P, Q278H, T286A, V292VI, I293V, P294T, E297A |
| >RG070| codons 1-335 PISSIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICAELENDGKISKIGPENPYNTPV FAIKKKNSTRWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRTKNPDIVI YQYVDDLYVGSDLEIGQHRAKIEELRAYLWKCGFYTPEQKHQKEPPFHWMGYELHPDKWT VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKHLCKLLRGAKALTEIVTLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQG |
References
| Author | Title | Citation |
| Dumans, AT | Synonymous genetic polymorphisms within Brazilian human immunodeficiency virus Type 1 subtypes may influence mutational routes to drug resistance. | J Infect Dis, 2004 |