Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 246 | 246 | Brazil | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 20 |
| 2 | AZT+ DDI | 43 |
| 3 | 3TC+ AZT | 62 |
| 4 | AZT+ DDI | 77 |
| 5 | 3TC+ D4T+ NFV | 132 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10V, K14R, G17D, L63P, A71T, I72T, N98K |
| >246| codons 1-99 PQITLWQRPVVTIRIGDQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKTTGTVLVGPTPVNIIGRNLLTQIGCTLKF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | K219Q | V118I, K122E, I135T, I178V, F214L |
| >246| codons 36-225 EICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIP HPAGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKG SPAIFQSSMTKILEPFRKQNPDVVIYQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGLT TPDQKHQKEP |
References
| Author | Title | Citation |
| Dumans, AT | Synonymous genetic polymorphisms within Brazilian human immunodeficiency virus Type 1 subtypes may influence mutational routes to drug resistance. | J Infect Dis, 2004 |