Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| RG046 | RG046 | Brazil | 2002 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+RTV | 8 |
| 2 | 3TC+AZT+NFV | 100 |
| 3 | 3TC+D4T+NFV | 81 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46ML, I54V, L90M | L10V, I15IV, K20R, E35D, M36V, N37E, R57K, D60E, Q61DN, I62V, L63LP, A71V, I72T, V77I, I93L |
| >RG046| codons 1-99 PQITLWQRPVVTIKVGGQLREALLDTGADDTVLEDVELPGRWKPKLIGGIGGFVKVKQYE DVPIEICGHKVTGTVLIGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74I, M184V, T215Y | D67DE | V35T, T39TA, K43Q, S68SG, V118VI, K122KE, I135V, S162X, E169D, K173A, Q174K, I178L, Q207A, H208Y, R211K, P243S, A272P, K277R, T286A, E291D, V292I, I293V, E297A |
| >RG046| codons 1-335 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAELEQEGKISKIGPENPYNTPV FAIKKKEGTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQXSMTKILDPFRAKNPDLVI YQYVDDLYVGSDLEIGQHRTKIEELRAYLLKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQSIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQG |
References
| Author | Title | Citation |
| Dumans, AT | Synonymous genetic polymorphisms within Brazilian human immunodeficiency virus Type 1 subtypes may influence mutational routes to drug resistance. | J Infect Dis, 2004 |