Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 215 | 215 | Brazil | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDI | 17 |
| 2 | None | 50 |
| 3 | 3TC+ D4T | 26 |
| 4 | 3TC+ D4T+ NFV+ NVP | 95 |
| 5 | 3TC+ D4T+ RTV+ SQV | 47 |
| 6 | 3TC+ ABC+ APV+ D4T | 17 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54L, I84V, L90M | L10F | N37T, L63P, H69K, A71V |
| >215| codons 1-99 PQITLWQRPFVTIKIGGQLKEALLDTGADDTVLEEMTLPGRWKPKMIGGIGGFLKVRQYD QIPIEICGKKVIGTVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, M184V | K70T | K103N, Y181C | S68G, D123E, I135T, G196E, T200A, F214L, H221Y |
| >215| codons 36-225 EICTEMEKEGKISKIGPENPYNTPVFAIKRKDGTTWRKLVDFRELNKRTQDFWEVQLGIP HPAGLKKNKSVTVLDVGDAYFSVPLDKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKG SPAIFQSSMTKILEPFRKQNPDIVICQYVDDLYVGSDLEIEQHRAKIEELRQHLLRWGLT TPDKKYQKEP |
References
| Author | Title | Citation |
| Dumans, AT | Synonymous genetic polymorphisms within Brazilian human immunodeficiency virus Type 1 subtypes may influence mutational routes to drug resistance. | J Infect Dis, 2004 |