Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ACTG364_777 | 777 | U.S. | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 227 |
| 2 | AZT+DDI | 182 |
| 3 | AZT+3TC | 94 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, T69D, K70R, M184V, T215FV | D67G, K219Q | K20KR, S48T, K64H, V118I, I135T, E138EQ, F214L, D218DE, L228H, A272AS, Q278H, A288T, T290TS | K259K* |
| >777| codons 1-292 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKEGKITKIGPENPYNTPV FAIHKKGSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSTNNQTPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGLVTPEQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQ*LVGKLNWASQIYSGIKVKHLCKLLRGTKTLSEV |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T4TA, I13IL, N37S, I64IV, V77I |
| >777| codons 1-99 PQIALWQRPLVTLKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD QILVEICGHKAIGTVLIGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Albrecht, MA | Nelfinavir, efavirenz, or both after the failure of nucleoside treatment of HIV infection.AIDS Clinical Trials Group 364 Study Team. | N Engl J Med, 2001 |