Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4303 | CA50892 | U.S. | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDC | 52 |
| 2 | DDI | 48 |
| 3 | 3TC+AZT | 18 |
| 4 | 3TC+AZT+IDV | 168 |
| 5 | ABC+D4T+EFV | 28 |
| 6 | 3TC+ABC+D4T | 44 |
| 7 | 3TC+D4T+LPV | 44 |
| 8 | 3TC+D4T+LPV+TDF | 35 |
| 9 | 3TC+D4T+LPV+T20+TDF | 31 |
| 10 | 3TC+D4T+LPV+TDF | 80 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, L76V, V82A | L10I, I15V, G16A, K20R, E35D, M36I, N37D, K55R, R57K, I62V, L63P, A71V, I93L |
| >CA50892| codons 1-99 PQITLWQRPIVTIKVAGQLREALLDTGADDTVLEDIDLPGRWKPKLIGGIGGFVRVKQYD QVPIEICGHKVIGTVVVGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, M184V, L210W, T215Y | K20R, E44D, V118I, I135T, S162SDGN, K173E, Q174K, D177E, G196GE, Q197E, K201KR, I202V, E203EK, Q207E, H208Y, R211K, H221C, V245K, A272P, K277KR, R284K, T286A, I293V, E297K | K43KHNQ |
| >CA50893| codons 1-300 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEQDGKISKIGPENPYNTPV FAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQNSMTKILEPFREKNPEIVI YQYVDDLYVGSDLEIEEHRTRVKELREYLWKWGFYTPDKKCQKEPPFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLKGAKALTEVVPLTKEAE |
References
| Author | Title | Citation |
| Rhee, SY | Genotypic predictors of human immunodeficiency virus type 1 drug resistance. | PNAS, 2006 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |