Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA3979 | CA50876 | U.S. | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 161 |
| 2 | 3TC+AZT+IDV | 13 |
| 3 | 3TC+AZT+SQV | 26 |
| 4 | 3TC+AZT+NFV | 65 |
| 5 | 3TC+DDI+NVP+RTV+SQV | 45 |
| 6 | None | 25 |
| 7 | ABC+D4T+LPV | 248 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F | I13IM, I15V, K20I, M36I, I62V, L63P, H69T, A71T, I72V, Q92QR |
| >CA50876| codons 1-99 PQITLWQRPFVTMKVGGQLIEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFVKVRQYD QVPIEICGTKTVGTVLVGPTPVNVIGRNLMTRIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184MV | T215I, K219EQ | K103N | K20R, K49KR, T69N, R83RK, K122E, D123E, D177E, I178M, F214L, V245E, A272P, E297K |
| >CA50877| codons 1-300 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISRIGPENPYNTPV FAIKKKNSNRWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGLITPDQKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTKEAE |
References
| Author | Title | Citation |
| Mitsuya, Y | N88D facilitates the co-occurrence of D30N and L90M and the development of multidrug resistance in HIV type 1 protease following nelfinavir treatment failure. | ARHR, 2006 |