Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1886 | CA5086 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ 3TC+ SQV | 52 |
| 2 | AZT+D4T+NFV | 87 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65KN | E28EV, I31IV, K49KE, K66X, R83K, S162C, I178L, V179I, T200A | E29ED, N54NS |
| >CA5086| codons 1-256 PISPIETVPVKLKPGMDGPKVKQWPLTVDKVKALVEICTEMEKEGKISEIGPESPYNTPV FAIKNXDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDLII YQYMDDLYVGSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVND |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | N83D | I13V, E35D, M36I, N37T, L63P |
| >CA5087| codons 1-99 PQITLWQRPLVTVKIGGQLKEALLDTGADNTVLEDITLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLVGPTPVDIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |