Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1270 | CA5085 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 52 |
| 2 | DDI | 52 |
| 3 | 3TC | 52 |
| 4 | D4T | 36 |
| 5 | AZT+SQV | 52 |
| 6 | NVP | 52 |
| 7 | AZT+IDV | 24 |
| 8 | D4T+RTV+SQV | 29 |
| 9 | 3TC+D4T+RTV+SQV | 30 |
| 10 | 3TC+D4T+IDV | 11 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V, L90M | G73S | K20I, N37D, L63P, A71V, I85V |
| >CA5085| codons 1-99 PQITLWQRPLVTIKIGGQLIEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKVISTVLVGPTPVNVVGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184I, L210W, T215Y | K101E, G190A | E44D, W88S, K166I, R211K |
| >CA5084| codons 1-264 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFSEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTIILEPFRKQNPDIVI YQYIDDLYVASDLEIGQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKL |
References
| Author | Title | Citation |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |