<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
cs190 cs190 Brazil 2001 HIV1 F Plasma None

Treatment History
Order Regimen Weeks
1 AZT+DDI 96
2 3TC+D4T+NFV 24

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V   L10I, I15V, K20T, E35D, M36I, N37E, P39Q, R41K, R57K, D60E, Q61D, H69Y  
>cs190| codons 1-99
PQITLWQRPIVTIKVGGQLTEALLDTGADDTVLEDIELQGKWKPKMIGGIGGFVKVKQYE
DILIEICGYKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, M184V, T215Y       V118I, D123E, I135T, K166R, E169D, K173A, Q174K, Q207E, R211K, F214L  
>cs190| codons 36-225
EICTELEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIP
HPAGLKKKKSVTVLDVGDAYFSIPLDKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKG
SPAIFQSSMTRILDPFRAKNPDIVIYQYVDDLYVGSDLEIGQHRTKIEELREHLLKWGLY
TPDKKHQKEP

References
Author Title Citation
Machado, ES Genotypic resistance and HIV-1 subtype in Brazilian children on dual and triple combination therapy. J Clin Virol, 2004