<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
cs189 cs189 Brazil 2001 HIV1 F Plasma None

Treatment History
Order Regimen Weeks
1 AZT 7
2 AZT+DDI 57
3 AZT+DDI+NFV 48
4 D4T+DDI+EFV 3

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
L90M   I15V, K20T, E35D, M36I, N37D, P39Q, R41K, R57K, D60E, Q61D, L89I  
>cs189| codons 1-99
PQITLWQRPLVTIKVGGQLTEALLDTGADDTVLEDIDLQGKWKPKMIGGIGGFIKVKQYE
DILIEICGHKAIGTVLVGPTPVNIIGRNIMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, M184V, T215Y       E53D, K104R, V118I, D123E, I135T, E169D, K173A, Q174K, E204D, Q207E, R211K, F214L  
>cs189| codons 36-225
EICTELEKEGKISKIGPDNPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIP
HPAGLKKKRSVTVLDVGDAYFSIPLDKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKG
SPAIFQSSMTKILDPFRAKNPDIVIYQYVDDLYVGSDLEIGQHRTKIEDLREHLLKWGLY
TPDKKHQKEP

References
Author Title Citation
Machado, ES Genotypic resistance and HIV-1 subtype in Brazilian children on dual and triple combination therapy. J Clin Virol, 2004