<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
TC-100 TC-100 Zimbabwe 2003 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 D4T+ DDI+ NVP 35
2 D4T+ 3TC+ NVP 13

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V   K101KE, K103KN, G190A   V35T, T39E, S48T, K122E, D123S, K173T, Q174K, D177E, Q197P, T200A, Q207E, V245T, D250E, A272P, K277R K20KN, K30KN, K220KE, N255IM
>TC-100| codons 1-283
PISPIETVPVKLKPGMDGPNVKQWPLTEENIKALTEICEEMEKEGKITKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKNKSVTVLDVGDAYFSVPL
DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTKNPEIVI
YQYVDDLYVASDLEIGPHRAKIEELREHLLRWGFTTPDKEHQKEPPFLWMGYELHPDKWT
VQPITLPEKESWTVIDIQKLVGKLNWASQIYPGIKVRQLCKLL

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I15V, L19I, M36I, R41K, D60E, Q61E, H69K, L89M, I93L  
>TC-100| codons 1-99
PQITLWQRPLVTIKVGGQIKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYE
EILIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF

References
Author Title Citation
Johnston, E High frequency of syncytium-inducing and CXCR4-tropic viruses among human immunodeficiency virus type 1 subtype C-infected patients receiving antiretroviral treatment. J Virol, 2003