Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TC-100 | TC-100 | Zimbabwe | 2003 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | D4T+ DDI+ NVP | 35 |
| 2 | D4T+ 3TC+ NVP | 13 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | K101KE, K103KN, G190A | V35T, T39E, S48T, K122E, D123S, K173T, Q174K, D177E, Q197P, T200A, Q207E, V245T, D250E, A272P, K277R | K20KN, K30KN, K220KE, N255IM |
| >TC-100| codons 1-283 PISPIETVPVKLKPGMDGPNVKQWPLTEENIKALTEICEEMEKEGKITKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKNKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTKNPEIVI YQYVDDLYVASDLEIGPHRAKIEELREHLLRWGFTTPDKEHQKEPPFLWMGYELHPDKWT VQPITLPEKESWTVIDIQKLVGKLNWASQIYPGIKVRQLCKLL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I15V, L19I, M36I, R41K, D60E, Q61E, H69K, L89M, I93L |
| >TC-100| codons 1-99 PQITLWQRPLVTIKVGGQIKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYE EILIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF |
References
| Author | Title | Citation |
| Johnston, E | High frequency of syncytium-inducing and CXCR4-tropic viruses among human immunodeficiency virus type 1 subtype C-infected patients receiving antiretroviral treatment. | J Virol, 2003 |