Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1869 | CA4999 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+IDV | 72 |
| 2 | D4T+DLV+RTV+SQV | 9 |
| 3 | 3TC+AZT+IDV | 44 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, V82A | L24I | L10I, I15V, R41K, L63P, T74S |
| >CA4999| codons 1-99 PQITLWQRPIVTIKVGGQLKEALIDTGADDTVLEEMNLPGKWKPKLIGGIGGFIKVRQYD QIPIEICGHKAIGSVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, T215Y | A98G | S3C, K20R, V35I, E44D, R83K, V111I, K166R, I167V, T200A, I202V, H208Y, L210S, H221Y, V245T, E248D, D250E, A272P, K277R, I293V |
| >CA4998| codons 1-294 PICPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKKTQDFWEVQLGIPHPGGLKKKKSVTVLDIGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRVLEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKVEELRQYLSRWGFYTPDKKYQKEPPFLWMGYELHPDKWT VQPITLPDKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVP |
References
| Author | Title | Citation |
| Kantor, R | Evolution of primary protease inhibitor resistance mutations during protease inhibitor salvage therapy. | AAC, 2002 |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |