Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1866 | CA4994 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 64 |
| 2 | AZT+DDC | 17 |
| 3 | AZT | 34 |
| 4 | AZT+IDV | 17 |
| 5 | IDV+DDI | 39 |
| 6 | 3TC+D4T+NVP | 58 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | A62V, V75I, K219R | V106A, G190A | F227L | K43N, E44D, W88C, V118I, K122E, I142IV, G196E, Q207E |
| >CA4994| codons 1-260 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELENDGKISKIGPENPYNTPV FVIKKKNSTKWRKLIDFRELNKRTQDFCEVQLGIPHPAGLKKKKSATVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVASDLEIEQHRTKIEELREHLWRWGFYTPDRKHQKEPPLLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90LM | R57K, L63P, A71V, I72E, V77I, I93L |
| >CA4995| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVKQYD QIPIEICGHKVEGTVLIGPTPVNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |