Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK5013 | TK5013a | Denmark | 2003 | HIV1 | D | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ AZT+ SQV | 14 |
| 2 | 3TC+ AZT+ IDV | 11 |
| 3 | 3TC+ IDV+ D4T | 95 |
| 4 | 3TC+ D4T+ NFV | 220 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30DN, M46MI, I54IV, V82VA | L24LI | L10LI, I15IV, K20KR, E35D, M36I, N37DE, R41K, D60DE, I62V, L63P, I64IV, E65ED, C67CY, T74TS |
| >TK5013a| codons 1-99 PQITLWQRPIVTIKVGGQLREALIDTGADNTVLEDIDLPGKWKPKIIGGIGGFVKVRQYE QVPVDIYGHKAIGSVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | A98G | V35I, E44D, S48E, V60I, V118VI, D121H, K122E, D177E, T200IL, I202IV, Q207E, R211K, V245K, A272P, K281KR, L282C, T286A, I293V, D324E |
| >TK5013a| codons 1-333 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKDGKIEKIGPENPYNTPI FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPL HEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYVDDLYVGSDLEIGQHRIKVEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRCLRGAKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQG |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |