Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK5012 | TK5012c | Denmark | 2003 | HIV1 | A | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ AZT+ IDV | 64 |
| 2 | ABC+ DDI+ EFV+ LPV | 151 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K101P, Y188L | K11T, V21VI, V35T, T39A, D121DN, S162SG, K173A, Q174K, D177E, V179I, I202V, Q207A, R211K, T240TA, V245Q, I257IV, T286A, E291D, I293V, P294T, E312D | Y146YC |
| >TK5012c| codons 1-334 PISPIETVPVTLKPGMDGPKIKQWPLTEEKIKALTEICAEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLPKKKSVTVLDVGDAYFSVPL NKDFRKYTAFTIPSINNETPGIRYQCNVLPQGWKGSPAIFQGSMTKILEPFRAKNPEIII YQYMDDLLVGSDLEIGQHRTKVEELRAHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWA VQPIQLPEKDSWTVNDVQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDVVTLTEEAE LELAENREILKDPVHGVYYDPSKDLIAEIQKQGQ |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10I, I13V, K14KR, G16E, K20R, E35D, M36I, R41K, L63ST, H69K, L89M | D25DG |
| >TK5012c| codons 1-99 PQITLWQRPIVTVRIEGQLREALLGTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD QISIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |