<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
TK5011 TK5011 Denmark 2002 HIV1 A Plasma None

Treatment History
Order Regimen Weeks
1 3TC+ AZT+ IDV 34
2 None 144
3 3TC+ AZT 59

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    L10V, I13IV, K14KR, E35D, M36I, R41K, R57K, H69K, L89M  
>TK5011| codons 1-99
PQITLWQRPVVTVRIGGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYD
QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V       K20R, V35T, T39E, K122E, D123S, I135IT, F171Y, K173S, Q174K, D177E, V179I, T200TI, I202IV, Q207A, R211S, F214FL, P243H, V245E, E248D, A272P, T286A, I293V, P294A  
>TK5011| codons 1-324
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICEEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPYRSKNPEIII
YQYVDDLYVGSDLEIGQHRIKVEELRAHLLSWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQHIELPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVVALTEEAE
LELAENREILKEPVHGVYYDPSKD

References
Author Title Citation
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005