Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK5008 | TK5008 | Denmark | 2002 | HIV1 | A | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ D4T+ IDV | 93 |
| 2 | D4T+ DDI+ EFV | 87 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T215Y | L100I, K103KN | K11T, V35T, E40D, I50V, V118I, K122E, D123S, T165L, K173S, D177E, V179I, T200A, Q207D, R211K, F214L, V245Q, A272T, K277R, T286A, E291D, I293V, P294T, E312N, Q332P, G335D |
| >TK5008| codons 1-340 PISPIETVPVTLKPGMDGPKVKQWPLTEEKIKALTEICTDMEKEGKISKVGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMLKILEPFRSQNPEIII YQYMDDLYVGSDLEIGQHRAKIEELRDHLLKWGLYTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYTGIKVRQLCKLLRGAKALTDVVTLTEEAE LELAENREILKNPVHGVYYDPSKDLIAEIQKPGQDQWTYQ |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I13V, G16E, K20R, E35D, M36I, R41K, R57K, H69K, K70R, L89M |
| >TK5008| codons 1-99 PQITLWQRPLVTVKIEGQLREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYD QILIEICGKRAIGTVLVGPTPVNIIGRNMLTQIGCTLNF |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |