<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
TK5008 TK5008 Denmark 2002 HIV1 A Plasma None

Treatment History
Order Regimen Weeks
1 3TC+ D4T+ IDV 93
2 D4T+ DDI+ EFV 87

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
T215Y   L100I, K103KN   K11T, V35T, E40D, I50V, V118I, K122E, D123S, T165L, K173S, D177E, V179I, T200A, Q207D, R211K, F214L, V245Q, A272T, K277R, T286A, E291D, I293V, P294T, E312N, Q332P, G335D  
>TK5008| codons 1-340
PISPIETVPVTLKPGMDGPKVKQWPLTEEKIKALTEICTDMEKEGKISKVGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL
DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMLKILEPFRSQNPEIII
YQYMDDLYVGSDLEIGQHRAKIEELRDHLLKWGLYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYTGIKVRQLCKLLRGAKALTDVVTLTEEAE
LELAENREILKNPVHGVYYDPSKDLIAEIQKPGQDQWTYQ

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I13V, G16E, K20R, E35D, M36I, R41K, R57K, H69K, K70R, L89M  
>TK5008| codons 1-99
PQITLWQRPLVTVKIEGQLREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYD
QILIEICGKRAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

References
Author Title Citation
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005