Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK5006 | TK5006a | Denmark | 2003 | HIV1 | D | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ AZT | 18 |
| 2 | 3TC+ AZT+ RTV+ SQV | 4 |
| 3 | 3TC+ AZT+ NVP | 98 |
| 4 | D4T+ DDI+ NFV | 79 |
| 5 | D4T+ 3TC+ LPV | 75 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V82VA, L90LM | Q58E | L10LI, R41K, L63AS, I64V, H69HY, I72IV, I85IV |
| >TK5006a| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVREYD QIAVEICGYKAVGTVLVGPTPANIVGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, M184V | K103KN | V35T, T39E, V60I, D121H, K122E, I135T, D177E, I178M, Y181X, T200TA, Q207E, T215X, V245E, D250E, A272P, T286A, I293V, P294T, T296TP, E297A, L301X |
| >TK5006a| codons 1-334 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICEELEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL HEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI XQYVDDLYVGSDLEIGQHRAKIEELREHLLRWGFXTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVVTLPAEAE XELAENREILKEPVHGVYYDPSKDLIAEIQKQGQ |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |