Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK5005 | TK5005 | Denmark | 2002 | HIV1 | A | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ AZT+ SQV | 21 |
| 2 | D4T+ DDC+ IDV | 64 |
| 3 | 3TC+ AZT+ RTV+ SQV | 8 |
| 4 | ABC+ NFV+ NVP | 4 |
| 5 | None | 1 |
| 6 | 3TC+ AZT+ NFV | 14 |
| 7 | 3TC+ AZT | 44 |
| 8 | 3TC+ AZT+ IDV+ RTV | 8 |
| 9 | 3TC+ AZT+ SQV | 28 |
| 10 | 3TC+ AZT+ EFV | 27 |
| 11 | 3TC+ NFV+ SQV | 2 |
| 12 | None | 27 |
| 13 | LPV | 31 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54T, V82A, L90M | L10I, I13V, K14R, G17D, K20R, E34N, E35D, M36I, R41K, R57K, D60E, I62V, L63P, H69K, A71V, L89I |
| >TK5005| codons 1-99 PQITLWQRPIVTVRIGDQLREALLDTGADDTVLNDINLPGKWKPKMIVGIGGFTKVKQYE QVPIEICGKKVIGTVLVGPTPANIIGRNIMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, T215F | K219Q | P4S, E6D, T27S, V35T, V60I, V118VI, K122E, D123S, I135T, K173S, Q174K, D177E, V179I, T200A, I202IV, Q207A, R211S, V245K, D250E, A272G, T286A, I293V, P294T, E312N |
| >TK5005| codons 1-324 PISSIDTVPVKLKPGMDGPKVKQWPLSEEKIKALTEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRSKNPEIII YQYMDDLYVGSDLEIGQHRAKVEELRAHLLSWGFFTPDQKHQKEPPFLWMGYELHPDKWT VQPIKLPEKESWTVNDIQKLVGKLNWASQIYGGIKVKQLCKLLRGAKALTEVVTLTEEAE LELAENREILKNPVHGVYYDPSKD |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |