Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK5004 | TK5004b | Denmark | 2002 | HIV1 | CRF01_AE | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 110 |
| 2 | None | 115 |
| 3 | 3TC+ AZT | 22 |
| 4 | 3TC+ AZT+ SQV | 58 |
| 5 | 3TC+ AZT+ IDV | 15 |
| 6 | 3TC+ D4T+ NFV | 22 |
| 7 | 3TC+ AZT | 27 |
| 8 | None | 36 |
| 9 | 3TC+ AZT+ EFV | 59 |
| 10 | IDV+ LPV+ RTV | 56 |
| 11 | 3TC+ D4T+ EFV | 13 |
| 12 | D4T+ EFV+ DDI+ LPV+ NFV | 11 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54AV, V82A | L89IV | L10I, V11VL, I13V, K14R, I15IV, K20I, E35D, M36I, R41K, H69K, K70R, A71AT |
| >TK5004b| codons 1-99 PQITLWQRPILTVRVGGQLIEALLDTGADDTVLEDINLPGKWKPKMIVGIGGFAKVRQYD QILIEICGKRTIGTVLVGPTPANIIGRNILTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K103KN | P4S, E6D, E28EA, K32E, V35I, T39K, K43E, E44D, V118I, K122E, D123S, I135T, S162C, K173T, Q174K, Q207A, R211N, V245E, E291D, I293V, E312T |
| >TK5004b| codons 1-324 PISSIDTVPVKLKPGMDGPKVKQWPLTAEKIEALIEICKELEEDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRTKNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRAHLWNWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTDVVPLTEEAE LELAENREILKTPVHGVYYDPSKD |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |