Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1846 | CA4950 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDC | 30 |
| 2 | AZT+D4T | 52 |
| 3 | AZT+DDI | 22 |
| 4 | 3TC+AZT+DDI+SQV | 13 |
| 5 | D4T+IDV | 17 |
| 6 | 3TC+D4T+IDV | 70 |
| 7 | DDI+NFV+NVP | 31 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, V75M, T215F | K219Q | Y181C, G190A | A98G | K20R, V35L, T39A, K43E, V60I, D86E, V118I, I135V, S162D, V179VI, G196E, E203K, R211K, F214L, L228H, A272P, T286A, K287KE, I293V, Q334L, G335S, R358K, A371AV, A376T, T386I, A400T, E432D, V467I, T470P, L491S, T497S, A554S | K259K*RW |
| >CA4950| codons 1-560 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICAELEEEGKISKIGPENPYNTPI FAIKKKNSDRWRKLMDFRELNKRTQEFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPDIII CQYMDDLYVASDLEIEQHRTKIKELRQHLLKWGLFTPDQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQWLVGKLNWASQIYPGIKVKQLCKLLRGAEALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLSQWTYQIYQEPFKNLKTGKYARMKGA HTNDVKQLTEVVQKITTESIVIWGKIPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKDPIVGAETFYVDGAANRETKLGKAGYVTDRGRQKVISLPDTTNQKTELQ AIHLALQDSGSEVNIVSDSQYALGIIQAQPDKSESELVSQIIEQLIKKEKVYLAWVPAHK GIGGNEQVDKLVSSGIRKVL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V, L90M | L10F | K20I, E35D, M36I, L63P, A71V, I72T |
| >CA4951| codons 1-99 PQITLWQRPFVTIKIGGQLIEALLDTGADDTVLEDINLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKVTGTVLVGPTPVNVIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |