Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK5001 | TK5001 | Denmark | 2003 | HIV1 | A | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 113 |
| 2 | 3TC+ D4T | 267 |
| 3 | 3TC+ D4T+ NVP+ TDF | 20 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, T215F | K219Q | Y181I | V108VI | E6K, K11T, K20R, V35T, T39L, L109I, V118I, K122E, D123N, S162D, K173T, Q174K, N175Y, D177E, V179I, Q197E, I202V, E203K, H208Y, R211K, D218E, L228H, V245Q, E248D, A272P, T286A, E291D, V292I, I293V, V317A | Q207DY |
| >TK5001| codons 1-334 PISPIKTVPVTLKPGMDGPRVKQWPLTEEKIKALTEICLELEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTIIDVGDAYFSIPL DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRTKYPEIII IQYMDDLYVGSDLEIGEHRTKVKELRDYLLKWGFFTPEQKHQKEPPFHWMGYELHPDKWT VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVPLTEEAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQGQ |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10I, I13V, K14R, E35D, M36I, R41K, R57K, L63T, H69K, V82I, L89M |
| >TK5001| codons 1-99 PQITLWQRPIVTVRIGGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYD QITIEICGKKAIGTVLVGPTPINIIGRNMLTQIGCTLNF |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |